Category: Publications
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Pyridoxal photoenzymes for asymmetric radical–radical cross-couplings
Cole C. Sorensen, Suhao Wang, Yao Ouyang, Saim Waheed, Claire G. Page, Greg Mann, Simon Allmendinger & Todd K. Hyster Nature, 2026, 657, 142-149
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Asymmetric Hydroamination Using Oxidative Radical Initiation in Flavin Enzymes
Alexandra C. Brown, Carlos E. Del Angel Aguilar, Felix C. Raps, Paul S. Riehl, Todd K. Hyster* J. Am. Chem. Soc., 2026, 148, 25, 25945–25956
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Photoenzymatic Hydroalkylation Enables Streamlined Access to Aryl Glutarimide Precursors
Zhi Xu, Prasun Mukherjee, Steven Gossert, Stephen Thomas, Vasil H. Vasilev, Eric R. Welin, Yichen Tan, Shane M. McKenna, Megan A. Emmanuel, Todd K. Hyster Angew. Chem. Int. Ed., 2026, e00006
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Photoenzymatic Csp3–Csp3 bond formation via enzyme-templated radical–radical coupling
Yi Liu, Daniel G. Oblinsky, Gianluca Dell’Orletta, Nico Di Fonte, Damien Sorigue, Claire G. Page, Isabella Daidone, Gregory D. Scholes, and Todd K. Hyster Proc. Natl. Acad. Sci. U.S.A., 123, 7, e2529018123
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Stereoselective Photoenzymatic Hydroarylation for the Construction of Quaternary Stereocenters
Felix C. Raps, Chufan A. Jin, Alexandra C. Brown, Damien Sorigué, Todd K. Hyster J. Am. Chem. Soc. 2025, 147, 44, 40547–40553
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Nucleophilic 𝛼-Functionalization of Benzyl Amines Using an Engineered Threonine Aldolase
Yao Ouyang, Suhao Wang, Damien Sorigué, Todd Hyster J. Am. Chem. Soc. 2025, 147, 29, 25184–25190
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Emergent Mechanisms in Biocatalysis
Felix C. Raps and Todd K. Hyster ACS Cent. Sci. 2025, 11, 7, 1029–1040
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Synergistic Photoenzymatic Anti-Markovnikov Hydroarylation of Olefins via Heteroaryl Radical Intermediates
Prasun Mukherjee, Zayed Alassad, Todd K. Hyster J. Am. Chem. Soc. 2025, 147, 17, 14048–14053.
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Unique Electron Donor–Acceptor Complex Conformation Ensures Both the Efficiency and Enantioselectivity of Photoinduced Radical Cyclization in a Non-natural Photoenzyme
Matteo Capone, Gianluca Dell’Orletta, Claire G. Page, Todd K. Hyster, Gregory D. Scholes, Isabella Daidone ACS Catal. 2024, 14, 16488-16496.
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Engineering a photoenzyme to use red light
Jose M. Carceller, Bhumika Jayee, Claire G. Page, Daniel G. Oblinsky, Gustavo Mondragón-Solórzano, Nithin Chintala, Jingzhe Cao, Zayed Alassad, Zheyu Zhang, Nathaniel White, Danny J. Diaz, Andrew D. Ellington, Gregory D. Scholes, Sijia S. Dong, Todd K. Hyster Chem 2025, 11, 1-11.