Author: nw10design
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Static to inducibly dynamic stereocontrol: The convergent use of racemic β-substituted ketones
Jacob S. DeHovitz, Yong Yao Loh, Jacob A. Kautzky, Kazunori Nagao, Andrew J. Meichan, Motoshi Yamauchi, David W. C. MacMillan, and Todd K. Hyster Science 2020, 369, 1113-1118
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Pyridoxal-Catalyzed Racemization of α-Aminoketones Enables the Stereodivergent Synthesis of 1,2-Amino Alcohols Using Ketoreductases
Jingzhe Cao and Todd K. Hyster ACS Catal. 2020, 10, 6171-6175
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Photoenzymatic Hydrogenation of Heteroaromatic Olefins Using ‘Ene’-Reductases with Photoredox Catalysts
Yuji Nakano, Michael J. Black, Andrew J. Meichan, Braddock A. Sandoval, Megan Chung, Kyle Biegasiewicz, Tianyu Zhu, and Todd K. Hyster Angew. Chem. Int. Ed. 2020, 59, 10484-10488
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Emerging strategies for expanding the toolbox of enzymes in biocatalysis
Braddock A. Sandoval and Todd K. Hyster Curr. Opin. Chem. Biol. 2020, 55, 45-51
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Asymmetric redox-neutral radical cyclization catalysed by flavin-dependent ‘ene’-reductases
Michael J. Black, Kyle F. Biegasiewicz, Andrew J. Meichan, Daniel G. Oblinsky, Bryan Kudisch, Gregory Scholes, and Todd Hyster Nat. Chem. 2019, 12, 71-75
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Photoexcitation of flavoenzymes enables a stereoselective radical cyclization
Kyle F. Biegasiewicz, Simon J. Cooper, Xin Gao, Daniel G. Oblinsky, Ji Hye Kim, Samuel E. Garfinkle, Leo A. Joyce, Braddock A. Sandoval, Gregory D. Scholes, and Todd K. Hyster Science 2019, 364, 1166-1169
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Radical Biocatalysis: Using Non-Natural Single Electron Transfer Mechanisms to Access New Enzymatic Functions
Todd K. Hyster Synlett 2020, 31, 3, 248-254
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Photoenzymatic Catalysis Enables Radical-Mediated Ketone Reduction in Ene-Reductases
Braddock A. Sandoval, Sarah I. Kurtoic, Megan M. Chung, Kyle F. Biegasiewicz, and Todd K. Hyster Angew. Chem. Int. Ed. 2019, 58, 8714-8718
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Biocatalytic hydrogen atom transfer: an invigorating approach to free-radical reactions
Yuji Nakano, Kyle F. Biegasiewicz, and Todd K. Hyster Curr. Opin. Chem. Biol. 2019, 49, 16-24
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Catalytic promiscuity enabled by photoredox catalysis in nicotinamide-dependent oxidoreductases
Kyle F. Biegasiewicz, Simon J. Cooper, Megan A. Emmanuel, David C. Miller, and Todd K. Hyster Nat. Chem. 2018, 10, 770